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Different Pharmaceutical Equipment Used To Make Tablets

 

Processing equipment

The tablet is the most common form of solid oral medication because it’s easier to manufacture, more affordable than capsules, comes in many varieties and has a long shelf life. The pharmaceutical industry also produces nutritional supplements in tablet forms. The food industry also produces tablet candies. Different industries usually use similar processing equipment to manufacture the tablets because the process for producing them is similar regardless of the industry.

Pharmaceutical Equipment For Tablet Manufacturing

Weighing Machine

Some may argue that weighing machines are the most valuable equipment in the tablet manufacturing process. It’s crucial to get accurate measurements of ingredients before mixing them to ensure that each tablet has precise doses. So manufacturers use high-precision electronic weighing machines to get accurate readings before the mixing process.

Mill

A mill is a piece of processing equipment that reduces the size of large materials into finer materials. Manufacturers usually use it to turn a solid substance into a fine powder. There are many types of mills in the market, though cone mills are popular among pharmaceuticals, food and other industries because they produce powders with consistent particle sizes.

Mixers

A mixer mixes the ingredients, usually in powdery forms, with each other to create the right blend needed to manufacture pills. There are three types of mixing machines; pneumatic or air-based mixers, tumbling or diffusion mixers and convective mixers. They are large enough to mix large batches of powders.

Granulators

A granulator is a piece of pharmaceutical equipment that creates granules out of either fine powder or larger substances. In tablet manufacturing, the granulator usually does the former. Depending on its design, the granulator may either use wet granulation (mix a volatile liquid with powder) or dry granulation (create granules without any liquid).

Sifters

Sifters or sieves are screens with pores that filter substances of different sizes. Manufacturers use them in the grinding process to make sure that the powder particles are small enough to pass through the pores. Many mill models come with detachable sieves of different sizes that manufacturers adjust as per their needs.

Dryers

As the name suggests, a dryer is drying equipment. If the tablet manufacturing process involves wet granulation, the manufacturer uses a dryer to dry the granules. The dryer provides ideal conditions for the volatile liquid used to form the granules to evaporate, leaving the granules behind. Common drying machines include fluidized bed dryers, rotary dryers, spray dryers, etc.

Tablet Compression Machines

This pharmaceutical equipment plays a key role in tablet manufacturing. As the name suggests, a tablet compression machine compresses the granules from all sides to create tablets of required sizes and shapes. You can find two types of tablet compression machines; a single-punch tablet press and a rotary or multi-station tablet press.

Deduster

Pills usually come out of the tablet press covered in a lot of dust. A dedusting machine removes the dust from each tablet’s surface through vibration and polishes it from all sides. The manufacturer can link the dust extractor to the tablet press. Types of dedusting machines include rotary vibrating deduster, uphill deduster, brush-type deduster and horizontal deduster.

Quality Control Equipment

Manufacturing firms use a variety of quality control equipment throughout the manufacturing process to test different quality indicators like thickness, strength, disintegration time, etc. These machines include tablet hardness tester, tablet thickness tester, disintegration equipment, USP dissolution tester, etc. These machines help manufacturers ensure that the tablets meet industry and health standards before packaging.

Coaters

The main issue with tablets is that they have a strong smell and taste. Manufacturers use used processing equipment called a coater to coat the pill’s smell and taste so that patients can swallow it easily. The machine usually sprays the coating on the pills while tumbling them. The coat dries quickly to prevent the pills from sticking to each other.

Packaging Machines

Once the manufacturing process is over, the factory packages the pills before shipping them. The type of package the firm uses depends on the level of protection they pills need, their cost, and the convenience of opening them. Packaging machines may package the pills into bottles, blister packs, aluminum foil, etc.

Equipment And Machinery Used In Pharmaceutical Tablet Manufacturing

Used Fitzmill

Used Fitzmill | Locate It Direct

Tablets are a popular form of oral medication that is made of active pharmaceutical ingredients and excipients. These dosages are available in different shapes, sizes, and thicknesses, etc. These tablets are manufactured using a different process, which requires a number of different machinery and equipment.

There are different types of tablets in the market and as such, the machinery used in the manufacture of the tablets is also different. From size-reduction equipment to granulators there are so many equipment involved the process and you can also use used pharmaceutical equipment like a used Fitzmill or a used tablet press for your production process. Here is a list of equipment involved in the manufacture of a tablet.

Size reducing equipment

Size-reduction equipment is essential for the tablet manufacturing process. Equipment like roller mills and hammer mills are used for the reduction of the size of the particles. For compressed tablets, it requires a certain size of the particles for producing uniform dosages of tablets. Fine sized particles are also essential for lubricants to mix with the granules. Apart from reducing the size of the particles, this equipment also performs important functions like reducing sensitivity in case of overcompensation while also improving the quality of the tablet.

Wet granulation equipment

This process involves the mixing of dry primary particles with the help of a granulating fluid and the sensitivity of this equipment calls for good quality processing equipment. Wet granulation process includes equipment like rotating shape granulators, high shear granulators, agitator granulators like a paddle or ribbon blender, orbiting screw mixer, planetary mixer or sigma blade mixer, etc.

Dry granulation equipment

This a process of mixing liquids without the use of granulating liquid and the dry granulation equipment needs to produce the right size of particles. Dry granulation is often used after wet granulation when the particles aren’t compressed properly or the drugs are moisture sensitive. The quality of a dry granulation machine depends on the roller design and speed, feed rate, die diameter and size of the particle. The dry granulation equipment includes spray dryers, rotary dryers, and fluid bed dryers, etc.

Mixing equipment

Mixing equipment are responsible for mixing the pharmaceutical ingredients that make the tablet together. The mixing is done with the help of mixers and blenders. Mixers are of various types including pneumatic mixers, diffusion mixers, air drive mixtures and orbiting screw mixtures, etc. Blenders are of different types as well like high-intensity blenders, ribbon blenders, and planetary blenders, etc.

Tablet compressing machine

This machine helps you compress the pharmaceutical ingredients into a tablet. Tablet compressing machines are mainly of two types, a single punch tablet press, and a rotary or multi-station tablet press. Single punch tablet presses are easy to use and thus have a high utilization ratio. This tablet press is perfect for use in small scale productions. Rotary tablet presses, on the other hand, are more complex and are used in large scale production of tablets. For capsule productions, capsule fillers are used to fill the capsule instead of compressing. You can also opt for a used capsule filler for the production.

Other pharmaceutical instruments

Apart from the basic pharmaceutical equipment mentioned above, there are a number of other equipment used in the tablet manufacturing process. The following are other tablet manufacturing equipment used in tablet production.

– Dissolution sampling machine
A dissolution sampling machine is used to analyze the ability of a tablet to dissolve in a solution.

– Friability tester
This equipment is used to test the durability of the equipment before it is packaged and sent for transit.

– Refractometers
Used to measure the refractive index of pharmaceutical solids.

– Freeze dryers
Freeze driers are used to store and stabilize various pharmaceutical drugs and biologicals.

– Melting point apparatus
A pharmaceutical melting point apparatus is used to measure the melting point and melting range of a particular substance.

– Packaging machines
Packaging machines like blister packaging machines and strip packaging machines are used to prepare pharmaceutical products for distribution. The machines can include label applicators, sealers, case packers, film wrappers, and hand packing stations, etc.